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AKBA Suppresses Inflammation

AKBA Suppresses Inflammation

You can find all NeuroScience supplements here at NeuroFormulas including the AKBA-containing product NorLox.


During the ancient times in India, it has been a practice in the Ayurvedic medical system to use Boswellin to treat arthritis, dysentery, liver diseases, obesity, neurological disorders, ringworm, boils, and other afflictions. The gum resin extract of Boswellin taken from the stem bark of the Boswellia serrata tree contains Acetyl-11-Keto-β-Boswellic Acid (AKBA). In modern times, this is still being used to treat the same ailments as they have during the ancient times in India, thus proving that there must be some truth in the effectiveness of AKBA to help cure these diseases.

In experiments, AKBA has been shown to be effective against arthritis, ulcerative colitis and Crohn's disease. AKBA has also manifested anti-tumor effects which were shown in its activity against brain tumors, leukemia cells and colon cancer cells. But the activities of AKBA are not yet clear. Various studies have been conducted to know how AKBA leads to being an anti-inflammatory substance.

AKBA has been shown to start cell cycle arrest. AKBA also blocks LPS-mediated production of TNF which is one of the most prevalent stimulants of inflammation. AKBA has been found to potentiate apoptosis induced by TNF and chemotherapeutic agents and stopped TNF-induced cell invasion. AKBA has also demonstrated the inhibition of 5-Lipoxygenase, inhibition of human leukocyte elastase and topoisomerase, calcium mobilization and the activation of MAP kinase and caspase. Boswellia serrata has also been found to inhibit ionophore-stimulated release of leukotrienes B4 and C4 from intact human polumorphonuclear neutropil leukocytes. Other researches also concluded that boswellic acids and derivatives such as AKBA decrease the formation of leukotriene B4 in rat peritoneal neutrophils. Along with other experiments, boswellic acid and AKBA proves to be a specific, non-reducing type inhibitors of leukotriene synthesis by either interacting directly with 5-lipoxygenase or by blocking its translocation.

 Leukotrienes being the fatty molecules of the immune system that contribute to inflammation, these activities of AKBA explain how it acts as an anti-inflammatory agent and its potentials to aid in the spread of cancer and possibly lead to a cure.

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