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How Certain Enzymes and Neurotoxins Affect the Functions of Acetylcholine

How Certain Enzymes and Neurotoxins Affect the Functions of Acetylcholine


This neurotransmitter is affected by Avipaxin and Daxitrol

Acetylcholine is a chemical compound and also a neurotransmitter found in both the central nervous system and the peripheral nervous system of humans and many other organisms. Acetylcholine is the only neurotransmitter of the somatic nervous system that is used in the body’s motor division. Acetylcholine is the neurotransmitter mainly responsible for the processes of all autonomic ganglia inside the body.


The enzyme by the name choline acetyltransferase is responsible for the synthesizing the acetylcholine in certain neurons. The second step is the conversion of acetylcholine into choline and acetate as an inactive metabolite by another enzyme called acetylcholineterase. The role of this enzyme in freeing the acetylcholine from the synapse is very important since the body requires abundant amount of acetylcholine at a quick rate to maintain a proper muscle function.


On the other hand, there are certain neurotoxins that inhibit some of the enzymes required by the acetylcholine to work properly. These neurotoxins are responsible for causing muscle paralysis that can lead to breathing problems and abnormal heartbeats. However there are certain ways on how to avoid having problems with neurotoxins that causes irregularities in the acetylcholine functions. There are a lot of acetylcholine related drugs that helps in many ways such as enhancing the body’s production of acetylcholine or clearing the neurotoxins in the body.


There are many other factors that can modify the ability of the body to respond from the effect of acetylcholine. Acetylcholine receptors are one of them. These receptors are located in different parts of the body, strategically placed so that they can response instantly upon the release of acetylcholine. When triggered, acetylcholine receptors are the ones that signal different chemical and physical processes to do their task and as a result cause the body to respond to what is being instructed by the brain.

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