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Introducing AKBA

Introducing AKBA

You can find all NeuroScience supplements here at NeuroFormulas including the AKBA-containing product NorLox.

 

Frankincense is one of the most famous incense for it was used in the Bible by one of the three kings and Boswellia or olibanum is a not as popular but very close relative of the infamous incense. This plant has also been used in the historical medical system of India known as the Ayurvedic. The gum resin extract of Boswellin taken from the stem bark of the Boswellia serrata tree contains Acetyl-11-Keto-β-Boswellic Acid (AKBA) which has been studied to have anti-inflammatory properties.

Even during the practice of the Ayurvedic in India,AKBA has been used to treat arthritis, dysentery, liver diseases, obesity, neurological disorders, ringworm, boils, and other afflictions. It is a pentacyclic terpenoid that is considered to be anti-inflammatory but the mechanism is poorly understood.

Backed up with at least 30 years of research, the traditional uses of AKBA in the Ayuvedric times have been confirmed to be true. In experiments, AKBA has been shown to be effective against arthritis, ulcerative colitis and Crohn's disease. AKBA has also manifested anti-tumor effects which were shown in its activity against brain tumors, leukemia cells and colon cancer cells.

AKBA has been shown to start cell cycle arrest. AKBA also blocks LPS-mediated production of TNF which is one of the most prevalent stimulants of inflammation. AKBA has been found to potentiate apoptosis induced by TNF and chemotherapeutic agents and stopped TNF-induced cell invasion. AKBA has also demonstrated the inhibition of 5-Lipoxygenase, inhibition of human leukocyte elastase and topoisomerase, calcium mobilization and the activation of MAP kinase and caspase. This activity of AKBA explains how it acts as an anti-inflammatory agent and its potentials to aid in the spread of cancer and possibly lead to a cure.

Boswellia supplements are also available and have been reported to be safe in humans but should not be used in children under 2 years of age. As with any other treatment, it is best to seek for a physician’s advice before use.


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