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Roles of Histamine in the Body

Roles of Histamine in the Body


Histamine is a body’s natural substance involved in the local immune response. It is an organic nitrogen compound that can also trigger inflammatory response. It also acts as a neurotransmitter and helps regulate the physiological function of the gastrointestinal tract. Histamines are produced and released by the mast cells and basophils and is nearly found in most connective tissues. Moreover, histamine can increase the permeability of the capillaries to protein and white blood cells in order for them to attack infected tissues and foreign invaders.

This neurotransmitter is related to ExcitaCor and AdreCor.


Below are the roles and effects of histamine in the body:


Regulation of sleep. Histamine is released as a neurotransmitter. The cell neuronal cell bodies that release histamines are found in the posterior hypothalamus. The histaminergic action is the one that regulates sleep. Classically, substances with antihistamine actions can produce sleep.


Neurologic studies have shown that these histamingergic cells produce a patter related to wakefulness. They fire slowly during relaxation and tiredness, fire rapidly when waking and completely stop during non-REM and REM sleep.


Suppressive effects. Histamines have stimulatory effects in neural cells. Aside from that, it also has suppressive actions that serve as protection against the risk of drug sensitization, convulsion, ischemic lesions, denervation supersensitivity and stress. It has also been suggested that histamine controls the mechanism by which learning and memories are forgotten.


Schizophrenia.  Histamine metabolites in the cerebrospinal fluids are increased in patients suffering from schizophrenia and at the same time, decreased binding of H1 receptor binding sites.


Erection and sexual function. Patients taking H2 antagonist drugs like ranitidine and cimetidine may experience erectile failure and libido loss. It has been suggested that taking H2 antagonist drugs may cause reduced uptake of testosterone that may lead to sexual difficulties. Men suffering from psychogenic impotence may be injected with histamine into the corpus cavernosum to produce partial or full erection.

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